$PROBLEM Theophylline

$INPUT ID AMT T=TIME DV WT EVID MDV

$DATA Data.prn IGNORE=@ 

$SUBROUTINE ADVAN2 

$PK
KA = THETA(1)*EXP(ETA(1))
K  = THETA(2)*EXP(ETA(2))
V  = THETA(3)*EXP(ETA(3))

S2=V/WT

$ERROR
Y=F+EPS(1)
IPRED = F
SD    = SQRT(SIGMA(1))
IWRES =(DV-IPRED)/SD


$ESTIM METHOD=1 INTERACTION MAXEVAL=5000 POSTHOC 

$COVARIANCE

$THETA (0,1) (0,0.5) (0,25)

$OMEGA 0.09 0.09 0.09
 
$SIGMA 0.5 

$TABLE IPRED IWRES



